Rabbit antithymocyte globulin

Repeat course of rabbit antithymocyte globulin as salvage following initial therapy with rabbit antithymocyte globulin in acquired aplastic anemia.

Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.

BACKGROUND In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse ATG is the standard therapy, rabbit ATG is more pot...

Tailored Rabbit Antithymocyte Globulin Induction Dosing for Kidney Transplantation

Background Rabbit antithymocyte globulin (rATG) is the most widely used kidney transplant induction immunotherapy in the United States. It was recently Food and Drug Administration approved for this indication with typical dose recommendations of 1.5 mg/kg for up to 7 days given via a central line. Methods We theorized that reduced rATG dosing when compared with conventional dosing (6-10.5 mg...

Facilitation of metastasis by antithymocyte globulin.

Antithymocyte globulin (ATG) increases the number, size, and rate of appearance of pulmonary métastasesin mice from implants of the syngeneic Lewis lung carcinoma (3LL) without significantly increasing the weight of the primary tumor. An attempt was therefore made to deter mine whether this effect was due to an earlier release of malignant cells from the primary tumor or to facilitation of the...

Antithymocyte globulin and transplants for aplastic anemia.

have completed a study on the use of antithymocyte globulin (ATG) as part of the conditioning regimen for severe aplastic anemia (SAA) patients, undergoing an allogeneic stem cell transplant (HSCT) from matched sibling (MSD) or unrelated (UD) donors. The Authors have found that rabbit ATG (thymoglobulin, Sanofi, France), as compared to horse ATG (ATGAM, Pfizer, USA) is associated with less acut...